Impact of chronic migraine attacks and their severity on the endogenous μ-opioid neurotransmission in the limbic system.

ABSTRACT:

Objective

To evaluate, in vivo, the impact of ongoing chronic migraine (CM) attacks on the endogenous μ-opioid neurotransmission.

Background

CM is associated with cognitive-emotional dysfunction. CM is commonly associated with frequent acute medication use, including opioids.

Methods

We scanned 15 migraine patients during the spontaneous headache attack (ictal phase): 7 individuals with CM and 8 with episodic migraine (EM), as well as 7 healthy controls (HC), using positron emission tomography (PET) with the selective μ-opioid receptor (μOR) radiotracer [¹¹C]carfentanil. Migraineurs were scanned in two paradigms, one with thermal pain threshold challenge applied to the site of the headache, and one without thermal challenge. Multivariable analysis was perfo

SUBMITTER: Jassar H 

PROVIDER: S-EPMC6612052 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature