Identification of the 12q24 locus associated with fish intake frequency by genome-wide meta-analysis in Japanese populations.

ABSTRACT:

Background

Japan is traditionally a country with one of the highest levels of fish consumption worldwide, although the westernization of the Japanese diet has resulted in the reduction of fish consumption. A recent meta-analysis of genome-wide association studies (GWASs) on Western populations has identified a single nucleotide polymorphism (SNP) associated with fish intake frequency. Here, we examined the genetic basis for fish intake frequency among Japanese individuals.

Results

We conducted a meta-analysis of a GWAS including 12,603 Japanese individuals and identified a susceptibility locus for fish intake frequency at 12q24 (lead variant was rs11066015, P = 5.4 × 10^-11). rs11066015 was in a strong linkage disequilibrium with rs671, a well-known SNP rela

SUBMITTER: Igarashi M 

PROVIDER: S-EPMC6612078 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature