Microbial differences between dental plaque and historic dental calculus are related to oral biofilm maturation stage.

ABSTRACT:

Background

Dental calculus, calcified oral plaque biofilm, contains microbial and host biomolecules that can be used to study historic microbiome communities and host responses. Dental calculus does not typically accumulate as much today as historically, and clinical oral microbiome research studies focus primarily on living dental plaque biofilm. However, plaque and calculus reflect different conditions of the oral biofilm, and the differences in microbial characteristics between the sample types have not yet been systematically explored. Here, we compare the microbial profiles of modern dental plaque, modern dental calculus, and historic dental calculus to establish expected differences between these substrates.

Results

Metagenomic data was generated from modern and histor

SUBMITTER: Velsko IM 

PROVIDER: S-EPMC6612086 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature