Effect of homeostatic T-cell proliferation in the vaccine responsiveness against influenza in elderly people.

ABSTRACT:

Background

Seasonal influenza virus infection is a significant cause of morbimortality in the elderly. However, there is poor vaccine efficacy in this population due to immunosenescence. We aimed to explore several homeostatic parameters in the elderly that could impact influenza vaccine responsiveness.

Methods

Subjects (> 60 years old) who were vaccinated against influenza virus were included, and the vaccine response was measured by a haemagglutination inhibition (HAI) test. At baseline, peripheral CD4 and CD8 T-cells were phenotypically characterized. Thymic function and the levels of different inflammation-related biomarkers, including Lipopolysaccharide Binding Protein (LBP) and anti-cytomegalovirus (CMV) IgG antibodies, were also measured.

Results

Influenza vacc

SUBMITTER: Herrero-Fernandez I 

PROVIDER: S-EPMC6612162 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature