Glyphosate induces benign monoclonal gammopathy and promotes multiple myeloma progression in mice.

ABSTRACT:

Background

Glyphosate is the most widely used herbicide in the USA and worldwide. There has been considerable debate about its carcinogenicity. Epidemiological studies suggest that multiple myeloma (MM) and non-Hodgkin lymphoma (NHL) have a positive and statistically significant association with glyphosate exposure. As a B cell genome mutator, activation-induced cytidine deaminase (AID) is a key pathogenic player in both MM and B cell NHL.

Methods

Vk*MYC is a mouse line with sporadic MYC activation in germinal center B cells and considered as the best available MM animal model. We treated Vk*MYC mice and wild-type mice with drinking water containing 1000 mg/L of glyphosate and examined animals after 72 weeks.

Results

Vk*MYC mice under glyphosate exposure developed pro

SUBMITTER: Wang L 

PROVIDER: S-EPMC6612199 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature