Surface PEGylation suppresses pulmonary effects of CuO in allergen-induced lung inflammation.

ABSTRACT:

Background

Copper oxide (CuO) nanomaterials are used in a wide range of industrial and commercial applications. These materials can be hazardous, especially if they are inhaled. As a result, the pulmonary effects of CuO nanomaterials have been studied in healthy subjects but limited knowledge exists today about their effects on lungs with allergic airway inflammation (AAI). The objective of this study was to investigate how pristine CuO modulates allergic lung inflammation and whether surface modifications can influence its reactivity. CuO and its carboxylated (CuO COOH), methylaminated (CuO NH₃) and PEGylated (CuO PEG) derivatives were administered here on four consecutive days via oropharyngeal aspiration in a mouse model of AAI. Standard genome-wide gene expression pr

SUBMITTER: Ilves M 

PROVIDER: S-EPMC6612204 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature