A pivotal role of androgen signaling in Notch-responsive cells in prostate development, maturation, and regeneration.

ABSTRACT: Androgen signaling is essential for prostate development, morphogenesis, and regeneration. Emerging evidence also indicates a regulatory role of Notch signaling in prostate development, differentiation, and growth. However, the collaborative regulatory mechanisms of androgen and Notch signaling during prostate development, growth, and regeneration are largely unknown. Hairy and Enhancer of Split 1 (Hes1) is a transcriptional regulator of Notch signaling pathways, and its expression is responsive to Notch signaling. Hes1-expressing cells have been shown to possess the regenerative capability to repopulate a variety of adult tissues. In this study, we developed new mouse models to directly assess the role of the androgen receptor in prostatic Hes1-expressing cells. Selective deletion of AR e

SUBMITTER: Aldahl J 

PROVIDER: S-EPMC6612318 | biostudies-literature | 2019 May - Jun

REPOSITORIES: biostudies-literature