Dataset Information
Mode-of-action of the PROPELLA concept in fulminant myocarditis.
Ontology highlight
ABSTRACT: Aims
Haemodynamic load induces cardiac remodelling via mechano-transduction pathways, which can further trigger inflammatory responses. We hypothesized that particularly in an inflammatory disorder such as myocarditis, a therapeutic strategy is required which, in addition to providing adequate circulatory support, unloads the left ventricle, decreases cardiac wall stress, and mitigates inflammatory responses.Methods and results
Axial flow pumps such as the Impella systems comply with these requirements. Here, we report a potential mode-of-action of prolonged Impella support (PROPELLA concept) in fulminant myocarditis, including a decrease in cardiac immune cell presence, and integrin α1, α5, α6, α10 and β6 expression during unloading.Conclusion
PROPELLA may provide benefits beyond its primary function of mechanical circulatory support in the form of additional disease-altering effects, which may contribute to enhanced myocardial recovery/remission in patients with chronic fulminant myocarditis.
SUBMITTER: Spillmann F
PROVIDER: S-EPMC6612367 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Mode-of-action of the PROPELLA concept in fulminant myocarditis.
European heart journal 20190701 26
<h4>Aims</h4>Haemodynamic load induces cardiac remodelling via mechano-transduction pathways, which can further trigger inflammatory responses. We hypothesized that particularly in an inflammatory disorder such as myocarditis, a therapeutic strategy is required which, in addition to providing adequate circulatory support, unloads the left ventricle, decreases cardiac wall stress, and mitigates inflammatory responses.<h4>Methods and results</h4>Axial flow pumps such as the Impella systems comply ...[more]