Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease.

ABSTRACT: Cardiovascular disease is a leading cause of death and reduced quality of life, proven by the latest data of the Global Burden of Disease Study, and is only gaining in prevalence worldwide. Clinical trials have identified chronic inflammatory disorders as cardiovascular risks, and recent research has revealed a contribution by various inflammatory cells to vascular oxidative stress. Atherosclerosis and cardiovascular disease are closely associated with inflammation, probably due to the close interaction of inflammation with oxidative stress. Classical therapies for inflammatory disorders have demonstrated protective effects in various models of cardiovascular disease; especially established drugs with pleiotropic immunomodulatory properties have proven beneficial cardiovascular effects; no

SUBMITTER: Steven S 

PROVIDER: S-EPMC6612399 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature