Morphology and development of a novel murine skeletal dysplasia.

ABSTRACT:

Background

Limb bones develop and grow by endochondral ossification, which is regulated by specific cell and molecular pathways. Changes in one or more of these pathways can have severe effects on normal skeletal development, leading to skeletal dysplasias. Many skeletal dysplasias are known to result from mis-expression of major genes involved in skeletal development, but the etiology of many skeletal dysplasias remains unknown. We investigated the morphology and development of a mouse line with an uncharacterized mutation exhibiting a skeletal dysplasia-like phenotype (Nabo).

Methods

We used µCT scanning and histology to comprehensively characterize the phenotype and its development, and to determine the developmental stage when this phenotype first appears.

Resu

SUBMITTER: Marchini M 

PROVIDER: S-EPMC6612423 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature