Dysfunctional Neural Processes Underlying Context Processing Deficits in Schizophrenia.

ABSTRACT:

Background

People with schizophrenia (PSZ) have profound deficits in context processing, an executive process that guides adaptive behaviors according to goals and stored contextual information. Although various neural processes are involved in context processing and are affected in PSZ, the core underlying neural dysfunction is unclear.

Methods

To determine the relative importance of neural dysfunctions within prefrontal cognitive control, sensory activity, and motor activity to context processing deficits in PSZ, we examined event-related potentials (ERPs) in 60 PSZ and 51 healthy control subjects during an optimal context processing task. We also analyzed the Ex-Gaussian reaction time distribution to examine abnormalities in motor control variability in PSZ.

Results

SUBMITTER: Kang SS 

PROVIDER: S-EPMC6612435 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature