Reduced Theta Power During Memory Retrieval in Depressed Adults.

ABSTRACT:

Background

Major depressive disorder (MDD) is associated with poor recollection, but the neural mechanisms responsible for this deficit are unclear. Recollection is supported by interactions between the hippocampus and cortex that appear to be mediated by oscillatory activity in the theta band (4-7 Hz) and that are elicited during source memory retrieval. Therefore, we tested the hypothesis that evoked theta power during source memory retrieval would be reduced in MDD, as this would provide a physiological basis for deficient recollection in adults with depression.

Methods

Morlet wavelets were applied to event-related potentials collected from 24 unmedicated adults with MDD and 24 healthy control adults during the retrieval of source and semantic memories. Whole-scalp analys

SUBMITTER: Kane J 

PROVIDER: S-EPMC6612457 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature