Disrupted modulation of thalamus activation and thalamocortical connectivity during dual task performance in schizophrenia.

ABSTRACT: Despite considerable evidence showing thalamus anatomy and connectivity abnormalities in schizophrenia, how these abnormalities are reflected in thalamus function during cognition is relatively understudied. Modulation of thalamic connectivity with the prefrontal cortex (PFC) is required for higher-order cognitive processes, which are often impaired in schizophrenia. To address this gap, we investigated how thalamus function and thalamus-PFC connectivity under different levels of cognitive demand may be disrupted in schizophrenia. Participants underwent fMRI scanning while performing an event-related two-alternative forced choice task under Single and Dual task conditions. In the Single task condition, participants responded either to a visual cue with a well-learned motor response, or an

SUBMITTER: Huang AS 

PROVIDER: S-EPMC6612476 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature