Ca_v 1.2 regulates osteogenesis of bone marrow-derived mesenchymal stem cells via canonical Wnt pathway in age-related osteoporosis.

ABSTRACT:

Aims

Age-related bone mass loss is one of the most prevalent diseases that afflict the elderly population. The decline in the osteogenic differentiation capacity of bone marrow-derived mesenchymal stem cells (BMMSCs) is regarded as one of the central mediators. Voltage-gated Ca²⁺ channels (VGCCs) play an important role in the regulation of various cell biological functions, and disruption of VGCCs is associated with several age-related cellular characteristics and systemic symptoms. However, whether and how VGCCs cause the decreased osteogenic differentiation abilities of BMMSCs have not been fully elucidated.

Methods

Voltage-gated Ca²⁺ channels related genes were screened, and the candidate gene was determined in several aging models. Functional role o

SUBMITTER: Fei D 

PROVIDER: S-EPMC6612635 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature