Phenotypical and functional heterogeneity of neural stem cells in the aged hippocampus.

ABSTRACT: Adult neurogenesis persists in the hippocampus of most mammal species during postnatal and adult life, including humans, although it declines markedly with age. The mechanisms driving the age-dependent decline of hippocampal neurogenesis are yet not fully understood. The progressive loss of neural stem cells (NSCs) is a main factor, but the true neurogenic output depends initially on the actual number of activated NSCs in each given time point. Because the fraction of activated NSCs remains constant relative to the total population, the real number of activated NSCs declines in parallel to the total NSC pool. We investigated aging-associated changes in NSCs and found that there are at least two distinct populations of NSCs. An alpha type, which maintains the classic type-1 radial morpholog

SUBMITTER: Martin-Suarez S 

PROVIDER: S-EPMC6612636 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature