EGFR mutant locally advanced non-small cell lung cancer is at increased risk of brain metastasis.

ABSTRACT:

Background and purpose

Small studies of primarily metastatic non-small cell lung cancer (NSCLC) have suggested an association between EGFR mutation (EGFR+) and likelihood of brain metastasis. However, these studies are confounded by follow-up time bias. We performed a competing risk analysis of brain metastasis in a more uniform locally advanced NSCLC (LA-NSCLC) cohort with known tumor genotype.

Materials and methods

Between 2002 and 2014, 255 patients with LA-NSCLC underwent tumor genotyping for EGFR, ALK and/or KRAS (180 patients had follow-up brain imaging). Cumulative incidence and Fine-Gray regression were performed on clinical variables including genotype and risk of brain metastasis, with death as a competing event.

Results

The proportion of tumors with aberrat

SUBMITTER: Mitra D 

PROVIDER: S-EPMC6612652 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature