The effect of exposure time and concentration of airborne PM_2.5 on lung injury in mice: A transcriptome analysis.

ABSTRACT: The association between airborne fine particulate matter (PM_2.5) concentration and the risk of respiratory diseases has been well documented by epidemiological studies. However, the mechanism underlying the harmful effect of PM_2.5 has not been fully understood. In this study, we exposed the C57BL/6J mice to airborne PM_2.5 for 3 months (mean daily concentration ~50 or ~110 μg/m³, defined as PM_2.5-3L or PM_2.5-3H) or 6 months (mean daily concentration ~50 μg/m³, defined as PM_2.5-6L) through a whole-body exposure system. Histological and biochemical analysis revealed that PM_2.5-3H exposure caused more severe lung injury than did PM_2.5-3L, and the difference was greater than that of PM<

SUBMITTER: Wang H 

PROVIDER: S-EPMC6612658 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature