Large-scale mammalian genome rearrangements coincide with chromatin interactions.

ABSTRACT:

Motivation

Genome rearrangements drastically change gene order along great stretches of a chromosome. There has been initial evidence that these apparently non-local events in the 1D sense may have breakpoints that are close in the 3D sense. We harness the power of the Double Cut and Join model of genome rearrangement, along with Hi-C chromosome conformation capture data to test this hypothesis between human and mouse.

Results

We devise novel statistical tests that show that indeed, rearrangement scenarios that transform the human into the mouse gene order are enriched for pairs of breakpoints that have frequent chromosome interactions. This is observed for both intra-chromosomal breakpoint pairs, as well as for inter-chromosomal pairs. For intra-chromosomal rearrangements,

SUBMITTER: Swenson KM 

PROVIDER: S-EPMC6612848 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature