Robust network inference using response logic.

ABSTRACT:

Motivation

A major challenge in molecular and cellular biology is to map out the regulatory networks of cells. As regulatory interactions can typically not be directly observed experimentally, various computational methods have been proposed to disentangling direct and indirect effects. Most of these rely on assumptions that are rarely met or cannot be adapted to a given context.

Results

We present a network inference method that is based on a simple response logic with minimal presumptions. It requires that we can experimentally observe whether or not some of the system's components respond to perturbations of some other components, and then identifies the directed networks that most accurately account for the observed propagation of the signal. To cope with the intractable

SUBMITTER: Gross T 

PROVIDER: S-EPMC6612863 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature