FunDMDeep-m6A: identification and prioritization of functional differential m6A methylation genes.

ABSTRACT:

Motivation

As the most abundant mammalian mRNA methylation, N6-methyladenosine (m6A) exists in >25% of human mRNAs and is involved in regulating many different aspects of mRNA metabolism, stem cell differentiation and diseases like cancer. However, our current knowledge about dynamic changes of m6A levels and how the change of m6A levels for a specific gene can play a role in certain biological processes like stem cell differentiation and diseases like cancer is largely elusive.

Results

To address this, we propose in this paper FunDMDeep-m6A a novel pipeline for identifying context-specific (e.g. disease versus normal, differentiated cells versus stem cells or gene knockdown cells versus wild-type cells) m6A-mediated functional genes. FunDMDeep-m6A includes, at the first ste

SUBMITTER: Zhang SY 

PROVIDER: S-EPMC6612877 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature