Dengue Underestimation in Guangzhou, China: Evidence of Seroprevalence in Communities With No Reported Cases Before a Large Outbreak in 2014.

ABSTRACT:

Objective

Dengue has become a serious public health problem in southern China particularly with a record-breaking outbreak in 2014. Serological evidence from areas with no known dengue cases reported prior to 2014 could provide information on possible unrecognized circulation of dengue virus (DENV) before this outbreak.

Method

Between March and May 2015, we performed a cross-sectional serosurvey using a stratified random sampling method among individuals aged 1-84 years-old in 7 communities in Guangzhou with no reported dengue cases before 2014. Sera of subjects were initially screened with the indirect DENV IgG enzyme-linked immunosorbent assay, and positive samples were further tested by the indirect immunofluorescence assay to identify specific serotypes.

Results

A

SUBMITTER: Jing Q 

PROVIDER: S-EPMC6612883 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature