MCS2: minimal coordinated supports for fast enumeration of minimal cut sets in metabolic networks.

ABSTRACT:

Motivation

Constraint-based modeling of metabolic networks helps researchers gain insight into the metabolic processes of many organisms, both prokaryotic and eukaryotic. Minimal cut sets (MCSs) are minimal sets of reactions whose inhibition blocks a target reaction in a metabolic network. Most approaches for finding the MCSs in constrained-based models require, either as an intermediate step or as a byproduct of the calculation, the computation of the set of elementary flux modes (EFMs), a convex basis for the valid flux vectors in the network. Recently, Ballerstein et al. proposed a method for computing the MCSs of a network without first computing its EFMs, by creating a dual network whose EFMs are a superset of the MCSs of the original network. However, their dual network is al

SUBMITTER: Miraskarshahi R 

PROVIDER: S-EPMC6612898 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature