Role of cerebellar GABAergic dysfunctions in the origins of essential tremor.

ABSTRACT: Essential tremor (ET) is among the most prevalent movement disorders, but its origins are elusive. The inferior olivary nucleus (ION) has been hypothesized as the prime generator of tremor because of the pacemaker properties of ION neurons, but structural and functional changes in ION are unlikely under ET. Abnormalities have instead been reported in the cerebello-thalamo-cortical network, including dysfunctions of the GABAergic projections from the cerebellar cortex to the dentate nucleus. It remains unclear, though, how tremor would relate to a dysfunction of cerebellar connectivity. To address this question, we built a computational model of the cortico-cerebello-thalamo-cortical loop. We simulated the effects of a progressive loss of GABA_A α₁-receptor subunits and

SUBMITTER: Zhang X 

PROVIDER: S-EPMC6612915 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature