Nanoencapsulated Quercetin Improves Cardioprotection during Hypoxia-Reoxygenation Injury through Preservation of Mitochondrial Function.

ABSTRACT: The effective delivery of antioxidants to the cells is hindered by their high metabolization rate. In this work, quercetin was encapsulated in poly(lactic-co-glycolic) acid (PLGA) nanoparticles. They were characterized in terms of its physicochemical properties (particle size distribution, ζ-potential, encapsulation efficiency, quercetin release and biological interactions with cardiac cells regarding nanoparticle association, and internalization and protective capability against relevant challenges). A better delivery of quercetin was achieved when encapsulated versus free. When the cells were challenged with antimycin A, it resulted in lower mitochondrial O₂ ^- (4.65- vs. 5.69- fold) and H₂O₂ rate production (1.15- vs. 1.73- fold). Simila

SUBMITTER: Lozano O 

PROVIDER: S-EPMC6612997 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature