Reproductive neuroendocrinology of mammalian gonadotropin-inhibitory hormone.

ABSTRACT:

Background

Gonadotropin-inhibitory hormone (GnIH) was discovered in the Japanese quail brain in 2000 as a hypothalamic neuropeptide that suppresses luteinizing hormone release from cultured quail anterior pituitary.

Methods

The authors investigated the existence of mammalian orthologous peptides to GnIH and their physiological functions in the following 19 years of research.

Main findings

Mammals have orthologous peptide to GnIH, often described RFamide-related peptide, expressed in the hypothalamus and gonads. Mammalian GnIH may also suppress gonadotropin synthesis and release by suppressing gonadotropin-releasing hormone (GnRH) synthesis and release in addition to directly suppressing gonadotropin synthesis and release from the pituitary. Mammalian GnIH may also sup

SUBMITTER: Ubuka T 

PROVIDER: S-EPMC6613023 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature