Differential left ventricular and left atrial remodelling in heart failure with preserved ejection fraction patients with and without diabetes.

ABSTRACT:

Background

Attempts to characterize cardiac structure in heart failure with preserved ejection fraction (HFpEF) in people with type 2 diabetes (T2D) have yielded inconsistent findings. We aimed to determine whether patients with HFpEF and T2D have a distinct pattern of cardiac remodelling compared with those without diabetes and whether remodelling was related to circulating markers of inflammation and fibrosis and clinical outcomes.

Methods

We recruited 140 patients with HFpEF (75 with T2D and 65 without). Participants underwent comprehensive cardiovascular phenotyping, including echocardiography, cardiac magnetic resonance imaging and plasma biomarker profiling.

Results

Patients with T2D were younger (age 70 ± 9 versus 75 ± 9y, p = 0.002), with evidenc

SUBMITTER: Gulsin GS 

PROVIDER: S-EPMC6613057 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature