Pattern of dopamine signaling during aversive events predicts active avoidance learning.

ABSTRACT: Learning to avoid aversive outcomes is an adaptive strategy to limit one's future exposure to stressful events. However, there is considerable variance in active avoidance learning across a population. The mesolimbic dopamine system contributes to behaviors elicited by aversive stimuli, although it is unclear if the heterogeneity in active avoidance learning is explained by differences in dopamine transmission. Furthermore, it is not known how dopamine signals evolve throughout active avoidance learning. To address these questions, we performed voltammetry recordings of dopamine release in the ventral medial striatum throughout training on inescapable footshock and signaled active avoidance tasks. This approach revealed differences in the pattern of dopamine signaling during the aversive c

SUBMITTER: Stelly CE 

PROVIDER: S-EPMC6613186 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature