Ontology highlight
ABSTRACT:
SUBMITTER: Wu L
PROVIDER: S-EPMC6613219 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Science translational medicine 20180701 448
The response of patients with gliomas to alkylating chemotherapy is heterogeneous. However, there are currently no universally accepted predictors of patient response to these agents. We identify the nuclear factor κB (NF-κB) co-regulator B cell CLL/lymphoma 3 (BCL-3) as an independent predictor of response to temozolomide (TMZ) treatment. In glioma patients with tumors that have a methylated <i>O</i><sup>6</sup>-methylguanine DNA methyltransferase (<i>MGMT</i>) promoter, high BCL-3 expression w ...[more]