Hypoglycaemia and treatment patterns among insulin-treated patients with type 2 diabetes who switched to insulin glargine 300 units/mL versus other basal insulin in a real-world setting.

ABSTRACT:

Introduction

Type 2 diabetes (T2D) is characterized by worsening pancreatic β-cell function often requiring treatment escalation with oral antidiabetic drugs (OADs), glucagon-like peptide-1 and eventually insulin. Although there is much evidence available on the initiation of basal insulins, fewer studies have investigated the effects of switching from one basal insulin to another. This study aims to evaluate treatment persistence and hypoglycaemia in adult patients with T2D on prior basal insulin who were switched to insulin glargine 300 units/mL (Gla-300) or other basal insulins in a real-world setting.

Materials and methods

This study is a retrospective cohort analysis of patient-level data extracted from the Optum^® Clinformatics^™ database between 1

SUBMITTER: Zhou FL 

PROVIDER: S-EPMC6613231 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature