Phenotypic spectrum of polycystic ovary syndrome and their relationship to the circadian biomarkers, melatonin and cortisol.

ABSTRACT:

Objective

Firstly, to investigate whether polycystic ovary syndrome (PCOS) shows a continuum of severity with increasing number of phenotypic features comprising the Rotterdam criteria for PCOS and secondly, to explore relationships of these phenotypes to the circadian biomarkers, cortisol and melatonin.

Background

Studies characterizing the spectrum of PCOS subphenotypes give little emphasis to the distinction among women who manifest zero, one or two of the three phenotypic features comprising the Rotterdam criteria. The relationship of circadian biomarkers to PCOS phenotypes is unclear.

Design

Cross-sectional study of 321 participants from 2011 to 2016 conducted at the National University Hospital (NUH), Singapore.

Participants

Participants included women wh

SUBMITTER: Lim AJR 

PROVIDER: S-EPMC6613235 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature