Integrative analysis of vascular endothelial cell genomic features identifies AIDA as a coronary artery disease candidate gene.

ABSTRACT:

Background

Genome-wide association studies (GWAS) have identified hundreds of loci associated with coronary artery disease (CAD) and blood pressure (BP) or hypertension. Many of these loci are not linked to traditional risk factors, nor do they include obvious candidate genes, complicating their functional characterization. We hypothesize that many GWAS loci associated with vascular diseases modulate endothelial functions. Endothelial cells play critical roles in regulating vascular homeostasis, such as roles in forming a selective barrier, inflammation, hemostasis, and vascular tone, and endothelial dysfunction is a hallmark of atherosclerosis and hypertension. To test this hypothesis, we generate an integrated map of gene expression, open chromatin region, and 3D interactions in

SUBMITTER: Lalonde S 

PROVIDER: S-EPMC6613242 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature