Observational study: 27 years of severe malaria surveillance in Kilifi, Kenya.

ABSTRACT:

Background

Many parts of Africa have witnessed reductions in Plasmodium falciparum transmission over the last 15 years. Since immunity to malaria is acquired more rapidly at higher transmission, the slower acquisition of immunity at lower transmission may partially offset the benefits of reductions in transmission. We examined the clinical spectrum of disease and predictors of mortality after sustained changes in transmission intensity, using data collected from 1989 to 2016.

Methods

We conducted a temporal observational analysis of 18,000 children, aged 14 days to 14 years old, who were admitted to Kilifi County Hospital, Kenya, from 1989 to 2016 with malaria. We describe the trends over time of the clinical and laboratory criteria for severe malaria and associated risk of

SUBMITTER: Njuguna P 

PROVIDER: S-EPMC6613255 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature