Association Between Androgen Deprivation Therapy Use and Diagnosis of Dementia in Men With Prostate Cancer.

ABSTRACT: Importance:The association between androgen deprivation therapy (ADT) exposure and dementia is uncertain. Objective:To analyze the association between ADT exposure and diagnosis of Alzheimer disease or dementia among elderly men with prostate cancer. Design, Setting, and Participants:This retrospective cohort study used data from the National Cancer Institute's Surveillance, Epidemiology, and End Results-Medicare linked database. Participants were 154 089 elderly men newly diagnosed with prostate cancer between 1996 and 2003. The analyses were conducted between November 1, 2018, and December 31, 2018. Exposure:Androgen deprivation therapy. Main Outcomes and Measures:Patients receiving ADT within 2 years of prostate cancer diagnosis were identified. Survival analysis was used to determine t

SUBMITTER: Jayadevappa R 

PROVIDER: S-EPMC6613289 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature