Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study.

ABSTRACT:

Importance

Genome-wide association studies (GWASs) in European populations have identified more than 100 schizophrenia-associated loci. A schizophrenia GWAS in a unique Indian population offers novel findings.

Objective

To discover and functionally evaluate genetic loci for schizophrenia in a GWAS of a unique Indian population.

Design, setting, and participants

This GWAS included a sample of affected individuals, family members, and unrelated cases and controls. Three thousand ninety-two individuals were recruited and diagnostically ascertained via medical records, hospitals, clinics, and clinical networks in Chennai and surrounding regions. Affected participants fulfilled DSM-IV diagnostic criteria for schizophrenia. Unrelated control participants had no personal or

SUBMITTER: Periyasamy S 

PROVIDER: S-EPMC6613304 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature