Association of Midlife Hearing Impairment With Late-Life Temporal Lobe Volume Loss.

ABSTRACT:

Importance

Hearing impairment (HI) in midlife (45-65 years of age) may be associated with longitudinal neurodegeneration of temporal lobe structures, a biomarker of early Alzheimer disease.

Objective

To evaluate the association of midlife HI with brain volume trajectories in later life (≥65 years of age).

Design, setting, and participants

This prospective cohort study used data from the Baltimore Longitudinal Study of Aging to evaluate hearing from November 5, 1990, to October 3, 1994, and late-life volume change from July 10, 2008, to January 29, 2015, using magnetic resonance imaging (MRI) (mean follow-up time, 19.3 years). Data analysis was performed from September 22, 2017, to August 27, 2018. A total of 194 community-dwelling older adults who had midlife measures

SUBMITTER: Armstrong NM 

PROVIDER: S-EPMC6613307 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature