Melatonin activity and receptor expression in endometrial tissue and endometriosis.

ABSTRACT:

Study question

Are melatonin receptors (melatonin receptor 1A (MR1A) and melatonin receptor 1B (MR1B)) expressed in human endometrium and endometriotic tissue, and does melatonin affect endometrial cell proliferation?

Summary answer

Melatonin receptors are expressed in human eutopic endometrium, endometriomas and peritoneal lesions, although to different extents, and melatonin treatment attenuated estradiol-induced endometrial epithelial cell proliferation in culture.

What is known already

Melatonin decreased endometriotic lesion volume in a rat model of endometriosis. Melatonin treatment reduced pain scores in and analgesic use by women with endometriosis.

Study design, size, duration

Basic science study using human endometrial tissue and an endometrial epithe

SUBMITTER: Mosher AA 

PROVIDER: S-EPMC6613342 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature