Kisspeptin regulation of human decidual stromal cells motility via FAK-Src intracellular tyrosine kinases.

ABSTRACT:

Study question

Can of Clinical Genetics, Maastricht University Medical Centre, Maastricht kisspeptin and its analogues regulate the motility of human decidual stromal cells and what intracellular signaling pathways are involved?

Summary answer

Kisspeptin analogue-mediated cell motility in human decidual stromal cells via the focal adhesion kinase (FAK)-steroid receptor coactivator (Src) pathway suggesting that kisspeptin may modulate embryo implantation and decidual programming in human pregnancy.

What is known already

The extravillous trophoblast invades the maternal decidua during embryo implantation and placentation. The motile behavior and invasive potential of decidual stromal cells regulate embryo implantation and programming of human pregnancy.

Study design,

SUBMITTER: Wu HM 

PROVIDER: S-EPMC6613344 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature