Curcumin ameliorates atrophy of seminal vesicle via reduction of oxidative stress in castrated mice.

ABSTRACT:

Background

The growth and function of seminal vesicle are dependent on androgen. This study was conducted to investigate the role of oxidative stress in castration-induced seminal vesicle atrophy and to explore the effects of curcumin, an antioxidant extracted from rhizome of turmeric, on seminal vesicle of castrated mice.

Methods

C57BL/6J mice were randomly divided into three groups: control, castration, and castration with curcumin (n = 10 for each group). After surgical castration, mice in the curcumin treatment group received intragastric administration of curcumin at 100 mg/kg body weight for 4 weeks, whereas mice in the other two groups were treated with olive oil. After that, the body weight, seminal vesicle weight and serum testosterone of mice were measured.

SUBMITTER: Li R 

PROVIDER: S-EPMC6613531 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature