Within-host infectious disease models accommodating cellular coinfection, with an application to influenza.

ABSTRACT: Within-host models are useful tools for understanding the processes regulating viral load dynamics. While existing models have considered a wide range of within-host processes, at their core these models have shown remarkable structural similarity. Specifically, the structure of these models generally consider target cells to be either uninfected or infected, with the possibility of accommodating further resolution (e.g. cells that are in an eclipse phase). Recent findings, however, indicate that cellular coinfection is the norm rather than the exception for many viral infectious diseases, and that cells with high multiplicity of infection are present over at least some duration of an infection. The reality of these cellular coinfection dynamics is not accommodated in current within-host m

SUBMITTER: Koelle K 

PROVIDER: S-EPMC6613536 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature