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Therapeutic Targeting of Notch Signaling Pathway in Hematological Malignancies.

ABSTRACT: The Notch pathway plays a key role in several processes, including stem-cell self-renewal, proliferation, and cell differentiation. Several studies identified recurrent mutations in hematological malignancies making Notch one of the most desirable targets in leukemia and lymphoma. The Notch signaling mediates resistance to therapy and controls cancer stem cells supporting the development of on-target therapeutic strategies to improve patients' outcome. In this brief review, we outline the therapeutic potential of targeting Notch pathway in T-cell acute jlymphoblastic leukemia, chronic lymphocytic leukemia, and mantle cell lymphoma.

SUBMITTER: Sorrentino C 

PROVIDER: S-EPMC6613627 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Therapeutic Targeting of Notch Signaling Pathway in Hematological Malignancies.

Sorrentino Claudia C   Cuneo Antonio A   Roti Giovanni G  

Mediterranean journal of hematology and infectious diseases 20190701 1

The Notch pathway plays a key role in several processes, including stem-cell self-renewal, proliferation, and cell differentiation. Several studies identified recurrent mutations in hematological malignancies making Notch one of the most desirable targets in leukemia and lymphoma. The Notch signaling mediates resistance to therapy and controls cancer stem cells supporting the development of on-target therapeutic strategies to improve patients' outcome. In this brief review, we outline the therap  ...[more]

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