Non-alcoholic fatty liver disease and colorectal cancer survival.

ABSTRACT:

Purpose

Liver diseases including non-alcoholic fatty liver disease (NAFLD) and ensuing alterations to the micro-environment may affect development of liver metastasis. Mirroring the rise in obesity rates, prevalence of NAFLD is increasing globally. Our objective was to examine the association between NAFLD and mortality in colorectal cancer patients.

Methods

Colorectal Cancer-Sarcopenia and Near-term Survival (C-SCANS) is a retrospective cohort study which included 3,262 stage I-III patients, aged 18-80 years, and diagnosed between 2006 and 2011 at Kaiser Permanente Northern California. Cox proportional hazards regression was used to calculate multivariable adjusted hazard ratios (HR) and 95% confidence intervals (CI).

Results

After up to 10 years of follow-up, 879 de

SUBMITTER: Wu K 

PROVIDER: S-EPMC6613648 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature