T vector velocity: A new ECG biomarker for identifying drug effects on cardiac ventricular repolarization.

ABSTRACT:

Background

We present a new family of ECG biomarkers for assessing drug effects on ventricular repolarization. We show that drugs blocking inward (depolarizing) ion currents cause a relative increase of the T vector velocity (TVV) and accelerate repolarization, while drugs blocking outward ion currents cause a relative decrease of the TVV and delay repolarization. The results suggest a link between the TVV and the instantaneous change of the cellular action potentials that may contribute to bridge the gap between the surface ECG and myocardial cellular processes.

Methods

We measure TVV as the time required to reach X% of the total Trajectory length of the T vector loop, denoted as TrX. Applied to data from two FDA funded studies (22+22 subjects, 5232+4208 ECGs) which target

SUBMITTER: Bystricky W 

PROVIDER: S-EPMC6613676 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature