Alcohol-induced changes in the gut microbiome and metabolome of rhesus macaques.

ABSTRACT:

Rationale

Increasing evidence has demonstrated that changes in the gut microbiome, including those associated with dietary influences, are associated with alterations in many physiological processes. Alcohol consumption is common across human cultures and is likely to have a major effect on the gut microbiome, but there remains a paucity of information on its effects in primates.

Objectives

The effects of chronic alcohol consumption on the primate gut microbiome and metabolome were studied in rhesus macaques that were freely drinking alcohol. The objectives of the study were to determine what changes occurred in the gut microbiome following long-term exposure to alcohol and if these changes were reversible following a period of abstinence.

Methods

Animals consuming al

SUBMITTER: Zhang X 

PROVIDER: S-EPMC6613802 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature