Evolution of spatial and temporal features of functional brain networks across the lifespan.

ABSTRACT: Development and aging are associated with functional changes in the brain across the lifespan. These changes manifest in a variety of spatial and temporal features of resting state functional MRI (rs-fMRI) but have seldom been explored exhaustively. We present a comprehensive study assessing age-related changes in spatial and temporal features of blind-source separated components identified by independent vector analysis (IVA) in a cross-sectional lifespan sample (ages 6-85 years). We show that while large-scale network configurations remain consistent throughout the lifespan, changes persist in both local and global organization of these networks. We show that the spatial extent of the majority of functional networks exhibits linear decreases and both positive and negative quadratic traje

SUBMITTER: Vij SG 

PROVIDER: S-EPMC6613816 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature