Overdose following initiation of naltrexone and buprenorphine medication treatment for opioid use disorder in a United States commercially insured cohort.

ABSTRACT:

Background and aims

Despite the growing opioid overdose crisis, medication treatment for opioid use disorder remains uncommon. The comparative effectiveness of buprenorphine and naltrexone treatment in reducing overdose and the comparative risks of discontinuing treatment in the real world, remain uncertain. Our aim was to examine the effectiveness of medications for opioid use disorder in preventing opioid-related overdose.

Design

Retrospective cohort study SETTING: United States.

Patients

46,846 commercially insured individuals diagnosed with opioid use disorder and initiating medication treatment between 2010 and 2016.

Measurements

Opioid-related overdose identified by International Classification of Diseases, Ninth and Tenth Revisions.

Findings

In ou

SUBMITTER: Morgan JR 

PROVIDER: S-EPMC6613830 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature