Altered Functional Connectivity of the Amygdala and Sex Differences in Functional Dyspepsia.

ABSTRACT:

Introduction

The influence of sex on the prevalence and clinical manifestations of functional dyspepsia (FD) has recently been a topic of increasing interest. However, brain MRI pathology based on sexual dimorphism in FD has not yet been investigated. The amygdala, which plays a vital role in processing gastrointestinal signals, may be associated with the sex-related pathophysiology of FD.

Methods

We investigated the resting-state functional connectivity (rsFC) of amygdala subregions in patients with FD and healthy subjects as well as the sex differences between male and female FD patients.

Results

The results showed that FD patients manifested altered rsFC in the basolateral amygdala (BLA) and centromedial amygdala subregions compared with HS and that female FD patie

SUBMITTER: Zeng F 

PROVIDER: S-EPMC6613861 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature