Radiation induces EIF2AK3/PERK and ERN1/IRE1 mediated pro-survival autophagy.

ABSTRACT: Cellular effects of ionizing radiation include oxidative damage to macromolecules, unfolded protein response (UPR) and metabolic imbalances. Oxidative stress and UPR have been shown to induce macroautophagy/autophagy in a context-dependent manner and are crucial factors in determining the fate of irradiated cells. However, an in-depth analysis of the relationship between radiation-induced damage and autophagy has not been explored. In the present study, we investigated the relationship between radiation-induced oxidative stress, UPR and autophagy in murine macrophage cells. A close association was observed between radiation-induced oxidative burst, UPR and induction of autophagy, with the possible involvement of EIF2AK3/PERK (eukaryotic translation initiation factor 2 alpha kinase 3) and E

SUBMITTER: Chaurasia M 

PROVIDER: S-EPMC6613886 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature