A pilot metabolomics study of tuberculosis immune reconstitution inflammatory syndrome.

ABSTRACT:

Background

Diagnosis of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is challenging and new tools are needed for early diagnosis as well as to understand the biochemical events that underlie the pathology in TB-IRIS.

Methods

Plasma samples were obtained from participants from a randomized HIV/TB treatment strategy study (AIDS Clinical Trials Group [ACTG] A5221) with (n = 26) and without TB-IRIS (n = 22) for an untargeted metabolomics pilot study by liquid-chromatography mass spectrometry. The metabolic profile of these participants was compared at the study entry and as close to the diagnosis of TB-IRIS as possible (TB-IRIS window). Molecular features with p < 0.05 and log₂ fold change ≥0.58 were submitted for pathway a

SUBMITTER: Silva CAM 

PROVIDER: S-EPMC6613934 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature