Review of Metformin Use for Type 2 Diabetes Prevention.

ABSTRACT:

Context

Prediabetes is prevalent and significantly increases lifetime risk of progression to type 2 diabetes. This review summarizes the evidence surrounding metformin use for type 2 diabetes prevention.

Evidence acquisition

Articles published between 1998 and 2017 examining metformin use for the primary indication of diabetes prevention available on MEDLINE.

Evidence synthesis

Forty articles met inclusion criteria and were summarized into four general categories: (1) RCTs of metformin use for diabetes prevention (n=7 and n=2 follow-up analyses); (2) observational analyses examining metformin use in heterogeneous subgroups of patients with prediabetes (n=9 from the Diabetes Prevention Program, n=1 from the biguanides and the prevention of the risk of obesity [BIGPRO]

SUBMITTER: Moin T 

PROVIDER: S-EPMC6613947 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature