Circuit Robustness to Temperature Perturbation Is Altered by Neuromodulators.

ABSTRACT: In the ocean, the crab Cancer borealis is subject to daily and seasonal temperature changes. Previous work, done in the presence of descending modulatory inputs, had shown that the pyloric rhythm of the crab increases in frequency as temperature increases but maintains its characteristic phase relationships until it "crashes" at extremely high temperatures. To study the interaction between neuromodulators and temperature perturbations, we studied the effects of temperature on preparations from which the descending modulatory inputs were removed. Under these conditions, the pyloric rhythm was destabilized. We then studied the effects of temperature on preparations in the presence of oxotremorine, proctolin, and serotonin. Oxotremorine and proctolin enhanced the robustness of the pyloric rhy

SUBMITTER: Haddad SA 

PROVIDER: S-EPMC6613981 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature